Medical advisers to the Food and Drug Administration say that prescription drugs containing codeine should not be used to treat children or the majority of teens suffering from pain or a cough.
In their meeting Thursday, the advisers also voted overwhelmingly against the over-the-counter sales of codeine-containing cough syrup for children. Selling such products without a prescription is currently permitted in 28 states and the District of Columbia.
The votes to restrict codeine's use among children came at the end of a daylong joint meeting of the FDA's Pulmonary-Allergy Drugs Advisory Committee and Drug Safety and Risk Management Advisory Committee, in Silver Spring, Md. The FDA does not have to follow the recommendations of its advisory committees, but it usually does.
"My concern, were I to be prescribing codeine in children, would be that I would, frankly, kill them," said pharmacist Maria Pruchnicki, of the Ohio State University College of Pharmacy.
Several committee members noted that there are questions about whether codeine is even effective for alleviating children's coughs, and whether there are potentially safer alternatives for alleviating pain.
Although the administration of products containing codeine to children has dropped sharply over the past decade, doctors often still prescribe medicines that contain the drug, and parents can buy cough remedies that include codeine without a prescription in many parts of the country.
Codeine combined with other painkillers, such as acetaminophen, is also commonly used to alleviate kids' pain in a variety of situations, such as when they're recovering from surgery.
But the FDA has been increasingly concerned because codeine has been found to trigger life-threatening breathing problems in some children.
Such complications seem to be fairly rare, but they do occur — especially among children whose bodies are genetically predisposed to quickly convert codeine into morphine.
The FDA convened the panel of outside experts to advise the agency on what action to take, if any, in restricting the drug's use.
During the hearing, FDA scientists made presentations on dozens of frightening cases in which children stopped breathing after getting codeine, including at least two dozen deaths in the past decade.
Also, representatives from the American Academy of Pediatrics and the National Center for Health Research, an advocacy group in Washington, D.C., urged the FDA to follow the lead of regulators in Europe, Australia and Canada, who have sharply restricted the drug's use.
"The use of codeine or any other opioid cannot be recommended for the treatment of cough in children," said Dr. Constance Houck, an anesthesiologist at Boston Children's Hospital, speaking on behalf of the academy. The pediatricians' group recommended against using codeine for pain and urged the FDA to bar the sale of products containing the drug without a prescription.
The Consumer Healthcare Products Association, which represents companies that make over-the-counter codeine products, urged the FDA to base any decision "on sound scientific evidence."
The manufacturers' association reminded the agency that codeine had been deemed earlier "to be generally recognized as safe and effective" and that any decision to remove codeine from over-the-counter sales should go "through a multistep process."
AUDIE CORNISH, HOST:
The Food and Drug Administration should impose tough new restrictions on giving products containing codeine to kids. That's the recommendation today from an FDA advisory committee. Here's NPR health correspondent Rob Stein.
ROB STEIN, BYLINE: When kids get back coughs, parents and doctors often give them remedies that contain codeine. Codeine's also combined with other drugs to help kids who are in pain, like after they've had an operation.
But the FDA's been getting more and more worried about kids getting codeine. That's because it can cause some children to stop breathing. This is rare, but it can happen, especially in kids whose bodies quickly convert codeine into morphine. The panel heard about dozens of frightening cases when kids stopped breathing, including at least two dozen deaths. Several panel members noted that there are big questions about whether codeine can really even help kids' coughs. And there are other drugs that may be much safer painkillers.
At the end of the day, the committee voted overwhelmingly to recommend against letting anyone under the age of 18 get prescription drugs containing codeine to treat coughs or pain. Maria Pruchnicki of Ohio State University is a member of the committee.
MARIA PRUCHNICKI: My concern were I to be prescribing codeine in children would be that I would, frankly, kill them.
STEIN: The committee also voted by a wide margin that codeine products for use by kids should no longer be sold without a prescription. The FDA doesn't have to follow the recommendations of its advisory committees, but the agency usually does. Rob Stein, NPR News. Transcript provided by NPR, Copyright NPR.